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The Maximum Lifetime of an Individual is Determined by Aging – What Exactly is Aging?

Aging is the set of morphological and physiological modifications that appear as a consequence of time. It leads to a reduction of the adaptive capacity of organs and systems as well as the responsiveness to harmful agents. It is a progressive biological process of most of the higher organisms that gradually leads to the loss of normal organ function and ends up with death. The maximum lifetime that an individual can reach is decisively determined by aging. Primary aging, also called physiological aging, is caused by cellular processes of aging which occur in the absence of diseases. It defines the “maximum attainable age” for an organism. Secondary aging, on the other hand, is the effect of external influences that shorten the maximum attainable age. Diseases, lack of exercise, defect symptoms or drug use for example can therefore influence the process of aging. Aging has many signs and affects some of our major body systems. It is not limited to the obvious effects on skin and hair – loss of efficiency of the heart muscle, thinning of the iris and lens, stiffing of joints and decease of neuronal connections are just a selection of effects. Furthermore, there are severe aging associated diseases such as cancer, Alzheimer`s disease, diabetes mellitus type 2, effort incontinence, myocardial infarction and osteoporosis.

Aging at The Cellular Level – Where It Begins and Where It Can be Stopped

At the cellular level, aging represents the progressive accumulation of sublethal lesions that can lead to cell death or at least a decrease in the cell’s ability to respond to the lesion. Additionally, various cellular functions like the mitochondrial oxidative phosphorylation, nucleic acid synthesis, structural and enzymatic proteins, cellular receptors and transcription factors progressively deteriorate with increasing age. Aged cells have a reduced ability to collect nutrients and repair chromosomal lesions. At the same time, there is a progressive accumulation of the age pigment lipofuscin, a product of lipid peroxidation and protein oxidation and indicator for oxidative stress. The accumulation leads to a decreased cell function and tissues and organs will begin to deteriorate. Subsequently, if enough molecules are damaged, health will decline. Naturally, a cell can undergo a certain number of divisions before it enters a dormant state of cell cycle arrest called “senescence”. Senescence can be triggered by the telomere length, epigenetic clock and DNA damage. With increasing age, the number of senescent cells also increases. In that dormant state, the cells stop dividing and remain “silent” for many years bypassing apoptosis (programmed cell death). Senescent cells are not considered benign because they are one cause of aging, show oncogenic paracrine activities that stimulate cell proliferation and because they secrete cytokines, chemokines and proteases (senescence associated secretory phenotype, SASP). These accumulated proteases promote chronic tissue inflammation and tissue deterioration (please click here if you want to know more about senescence).

Current Treatment Methods for Anti-Aging – an Overview

Easy and traditional methods use natural oils, anti-oxidants, special diet programs, vitamins, alpha hydroxyl acids, hormones, petroleum-based products (in beauty creams) or sulfates to treat aging skin. Conventional anti-aging treatments are offered by innumerable practitioners worldwide. Often, they include microdermabrasion, chemical peeling, botox injections, fillers, laser surfacing, latisse and sclerotherapy. Sclerotherapy uses saline injections to eliminate unsightly large veins that are close to the skin’s surface, veins may turn into scar tissue that fades. Latisse is a treatment using bimatoprost to stimulate hair growth at the root. Known side effects are burning of the eyes and darkening of the iris. The effects of fillers (wrinkle or dermal fillers like collagen and hyaluronic acid are used to fill in lines and help lifting certain areas), botox injections (toxins reducing/erasing wrinkles by blocking muscle contractions), chemical peeling (chemical destruction of uppermost skin layer revealing a new one underneath) and microdermabrasion (skin smoothing and texture refinement by physically removing dry skin) only have a temporary effect on the skin as their results only last a limited time. Also, their anti-aging effects never go beyond the treated areas. Potential treatment methods for anti-aging reach from conventional anti-aging treatments to the approach of removing senescent cells or bypassing senescence. To recap, senescence is a dormant state of cell cycle arrest. The number of senescent cells increase with age and they secrete cytokines, chemokines and proteases (senescence associated secretory phenotype, SASP). Senoyltics are a new class of drugs used to remove senescent cells. They can extend lifespan and reduce age related symptoms. Glucocorticoids can repress SASP-induced inflammations from senescent cells but there are side effects and drug resistances (Soto-Gamez & Demaria, 2017). Metformin, an antidiabetic drug, shows an inhibitory effect on SASP and reduces oxidative stress ((Moiseeva et al., 2013; Martin-Montalvo et al., 2013). Phenols and flavonoids can also reduce oxidative stress (Pitozzi et al., 2013; Lim et al., 2015). Rapamycin can suppress SASP components that hold the arrested cell in senescence associated growth arrest (Soto-Gamez & Demaria, 2017). Also, by using JAK inhibitors, it was possible to enhance the efficacy of chemotherapy and achieve positive effects on age-related symptoms (Toso et al., 2015; Xu et al., 2015). Statins, lipid-lowering drugs, also showed to reduce the expression of pro-inflammatory SASP proteins due to protein prenylation (Liou et al., 2014). Another approach to reduce age related effects of the SASP is the use of monoclonal antibodies directed against SASP proteins (Mian et al., 2003; Karkera et al., 2011). Senolytic drugs like quercetin and dasatinib are also able to reduce age-related symptoms but showed only selective removal of senescent cells from different tissues (Soto-Gamez & Demaria, 2017). Unfortunately, there are many possible side effects and open questions regarding the removal or reprogramming of senescent cells that must be taken into consideration. Overcoming of growth arrest in cells with DNA damage or oncogenic activation may result in hyperplastic anomalies. Considering this, removal of senescent cells should be preferred instead of bypassing senescence (Soto-Gamez & Demaria, 2017). As senescent cells facilitate wound healing by reducing fibrosis and attracting immune cells, a delay in wound healing could be a possible outcome of senescent cell removal (Sagiv et al., 2013; Demaria et al., 2014).

Stem Cell Treatment For Anti-Aging Effects

As seen above, Aging can be treated with various mechanisms. This approach to Anti-Aging underlies a different method. Current studies show a protective effect of adipose-derived stem cells (ADSCs) for human dermal fibroblasts to prevent skin damage from free radicals, which is one of the factors of the aging process. The effects of the stem cells are not limited to anti-oxidation, but also include immuno-modulation effects which can reduce the aging process by moderation of the cytokine production. In the past, many medical treatments have been used to treat the symptoms of photo-aging, though without satisfying results. ADSCs secrete various growth factors which can both control and repair damaged skin cells. There is evidence that conditioned medium from ADSCs (short ADSC-CM), which contain stem cell secretome can stimulate collagen synthesis and migration of dermal fibroblasts, both of which can reduce skin-aging and quicken wound healing processes. But the anti-aging effects of stem cells are not limited to the skin. Stem cells and their secretome have been shown to have a regenerative effect on many organs and functional systems in the body:
  • Regeneration of impaired function of the kidneys and liver
  • Improved endo- and exocrine function of the pancreas
  • Reduction of insulin-tolerance in diabetes
  • Improved cognitive function
  • Increased production of sexual and growth hormones

Anova IRM Stem Cell Based Treatment Strategies for Aging

Stem cell based treatment strategies range from the direct application of mesenchymal stem cells (isolated from adipose tissue (ADSCs) or bone marrow) to mesenchymal stem cell conditioned medium (ADSC-CM ) that contains the stem cell secretome. Aging is by far the most important risk factor for diseases such as cancer, coronary heart disease, Alzheimer’s disease, Parkinson’s disease and chronic renal failure. ANOVA delivers the beneficial effects of secretome gained from mesenchymal stem cells (MSCs) in anti-aging, tailored to your specific needs, without the uncertainty and risk of treatments outside regulated medical systems. All stem cell procedures are in accordance with the strict quality standards of Germany and the respective healthcare regulations of the country where the treatment is administered. At ANOVA, we are not restricted to the secretome from stem cells. They are simply the latest addition to an increasingly effective medical treatment form to slow down and eventually reverse the effects of aging. To find out what is best for you, our specialists will subject you to a detailed check-up of your whole body before deciding on the specifics of the anti-aging treatment. The check-up team will help you to obtain a general idea of your body’s current status by comprising the following components:
  • In depth medical history
  • General physical exam
  • Personalized clinical chemistry (blood and urine)
  • Cardio-vascular check-up including EKG, Echocardiography, Cardio-CT and/or MRI, etc.
  • Cancer check with tumor markers, whole-body MRI, (virtual) colonoscopy, low-dose CT of the lungs (smoker), MR-mammography, etc.
Additional anti-aging measurements may include but are not limited to:
  • Hormone optimization
  • Metabolic and body composition optimization
  • Anti-oxidation treatment
  • Dietary optimization
  • Personalized exercise program
  • NAD+ precursors
  • Quercitin
  • Dasatinib
  • Navitoclax
  • Stem Cell Secretome
  • Autologous Growth facts i.e. from platelet rich plasma (PRP) concentrations
  • Targeted use of HGH
If you have any questions regarding our anti-aging treatment at ANOVA Institute for Regenerative Medicine, simply give us a call or contact us by e-mail. Contact us for more information, or make an appointment right away. Our specialists will be happy to advise you on the best therapy.

Medical treatments with Mesenchymal Stem Cells (MSCs)

Mesenchymal Stem Cells (MSCs) are one of the most famous stem cell type used in medicine. They have been shown to be effective for a wide range of diseases with a minimal risk profile. At the same time several hundred clinical studies are ongoing to investigate their regenerative abilities in greater detail. From a biological point-of-view, they are progenitor cells of connective tissues. This means that they are important for building and maintaining the healthy status of connective tissues throughout the whole body, and are known as stromal stem cells. Likewise, they possess the ability to differentiate into a spectrum of other cell types, including chondrocytes (cartilage cells), osteoblasts (bone cells), adipocytes (fat cells), etc. This property classifies them as “multipotent stem cells” (being able to transform into many cell types). There are several reasons of why they are the leading stem cell type in medical applications and clinical trials on humans:
  • They are relatively easy to harvest and be isolated from:
    • Fat tissue, known as adMSCs (adipose derived MSCs)
    • Bone Marrow, known as bmMSCs (bone marrow MSCs)
    • Umbilical Cord, known as ucMSC (umbilical cord MSCs)
  • MSCs are relatively stable to culture and expand in the laboratory
  • They can go through relatively many division cycles without losing their expression profile, health and division potential
  • Numerous animal, clinical and scientific data collected for various disease models, including neurodegenerative diseases
  • They possess little to no potential to grow into cancer cells
  • As recent research revealed, their stem cell secretome profile is extraordinarily beneficial because it displays a wide range of regenerative and protective abilities to the body.
  • As such, MSCs are our favorite source for making our Stem Cell Secretome therapies.

IMPORTANT 

The effects of anti aging treatment with stem cells can include:
  • A More Even Skin Tone
  • Reduction of Age Spots
  • Reduction of Fine Lines and Wrinkles
  • Increased energy and stamina
  • Improved Muscular Strength
  • The Slowing of the Effects of Degenerative Diseases
So, how exactly does stem cell anti aging treatment do all this, and more? There are five essential ways. The National Stem Cell Institute, a leading U.S. medical clinic in stem cell therapy technology, goes over all of them, and explains how anti aging treatment through stem cell therapy is performed.
  1. 1. Increasing The Body’s Stem Cell Count

Stem cells remain in the body throughout life. In fact, our bodies depend on these “adult” stem cells in order to keep us healthy and to repair damage of any kind, whether from injury, illness, or neurological conditions. Discovering that adult stem cells are so critical to health and disease prevention is counted as one of the most important health discoveries of modern medicine. From this discovery has sprung a golden age of stem cell therapy developments; among them, anti aging treatment. All adult stem cells originate in bone marrow. As we age, the production of stem cells begins to decline. The result is aging, age-related diseases and disorders, and a slowing in the body’s ability to heal after an injury or during illness. No amount of cosmetic surgery can be effective anti aging treatment for these. Declining levels of stem cells affect the skin’s ability to remain elastic and repair environmental damage Declining levels of adult stem cells mean damage can be essentially left un-repaired almost anywhere in or on the body. The older we get, the more our body’s defenses must decide where to use its dwindling resources. This means that repairing the effects of aging to the skin or hair line will gradually take a back seat to more pressing health matters. Anti aging treatment studies show that adult stem cell releases from the bone marrow drops at significant rates as we grow older.
  • At thirty-five years of age, stem cell release drops by forty-five percent
  • At fifty years of age, stem cell release drops by fifty percent
  • At sixty-five years of age, stem cell release drops by ninety percent
This means that, by the age of sixty-five, only ten percent of the body’s stem cells are circulating through the blood. Compare these percentages to that of infants, whose stem cell circulation rate is 100%. Stem cell therapy as an anti aging treatment helps to increase the levels of stem cells circulating through the bloodstream. By harvesting the cells from an easily accessed source –the fatty layer that lies just beneath the skin- a person’s own stem cells can be concentrated and released back into the bloodstream. There, the cells can resume fighting the root causes of low energy levels, the degenerative conditions related to aging, and restore the skin’s natural hydrating and regenerative abilities that give it the glow, elasticity, and firmness of youth.

2. Repairing The Damage Of Skin Due To Aging

With a greater number of adult stem cells circulating through the bloodstream, every organ in the body can more effectively fight the effects of disease and aging. Since the skin is the body’s largest organ it, too, is profoundly affected by the boost in stem cell circulation. Anti aging treatment via stem cell therapy results in the improvement of:
  • The skin’s elasticity and tightness
  • The reduction of fine lines and wrinkles
  • The evening of skin tone through lightening and clarifying
  • The reduction of sun damage
  • The reduction of the effects of environmental pollution
  • Increase of skin cell longevity
  • Promotion of healthy skin radiance
  1. 3. Repairing The Damage To Hair Follicles

There are a number of reasons why people lose their hair, from genetics to disease to environmental elements. In regard to age-related hair loss, both hair and scalp cells begin to deteriorate as we grow older. The thicker, longer hair of youth is replaced with the soft, white fuzzy hair so often associated with age. This happens to men and women alike. It’s caused by stem cells of the hair follicles falling dormant. Without proper signals from the surrounding area, the cells cannot begin to regenerate and continue to grow the thicker hair associated with youth. Stem cell therapy for hair loss in relation to anti aging treatment “jumpstarts” hair production. 4, An infusion of stem cells restores signaling When anti aging treatment includes stem cell therapy for hair loss, the infusion of stem cells restores those lost signals that cause hair growth. The fresh stem cells stimulate those that are already within –but are lying dormant- in the hair follicle. This causes the dormant cells to “wake up” and chemically signal hair growth. The fresh stem cells also construct and help to underpin the hair follicle papilla, which is the base of the follicle bulb. Comprised of connective tissue and capillary loops, the follicle bulb is an essential part of healthy hair. The result is ongoing, long term, permanent hair regeneration.
  1. 4. Repairing The Internal Damage Of Aging

Stem cells are the building blocks from which all repair, regeneration, and healing of the body arise. When adult stem cells flow abundantly through the bloodstream, they reach every organ and become whatever type of cell is needed to maintain the health of each one. A higher rate of stem cell circulation goes beyond the improvement of external signs of aging. Anti aging treatment thought stem cell therapy permeates deeply and throughout the body. Among the areas potentially addressed through stem cell anti aging treatment are:
  • Adrenal Glands
  • Appendix
  • Bladder
  • Brain
  • Eyes
  • Gall Bladder
  • Heart
  • Intestines
  • Kidneys
  • Liver
  • Lungs
  • Esophagus
  • Pancreas
  • Pituitary Gland
  • Prostate
  • Skin
  • Stomach
  • Thymus
  • Thyroid
  • Veins and Other Blood Vessels
Not surprisingly, then, stem cell therapy can go beyond anti aging treatment even when the intention is mostly to address the external affects of growing old. Among the age-related diseases and chronic conditions that stem cell therapy treats are:
  • Arthritis
  • Back Pain
  • Diabetes
  • Erectile Dysfunction (ED)
  • Female Sexual Dysfunction (FSD)
  • Joint Pain
  • Neuropathy
  1. 5. Restoring More Youthful Energy Levels

Anti aging treatment through stem cell therapy can ultimately result in far more than external improvement in skin quality and fuller hair. Since stem cells address a wide array of underlying conditions related to age, including the restoration of organ functions, energy levels are known to increase as tissues are repaired and inflammation from the cellular level on up is dramatically decreased. A number of age-related conditions can rob people of energy. Among them are:
  • Autoimmune Diseases
  • Osteoarthritis
  • Kidney Disease
  • Diabetes
  • Lung Related Diseases
  • Circulatory Conditions
Certainly, part of the reason stem cell therapy helps restore energy levels is because the relief of chronic symptoms, like pain, makes people feel better. But the repair of damaged organs means healthy tissue replaces that which is unhealthy. When that happens, fuller function is restored. Just as when an automobile performs better and with more pep after proper repairs are done so, too, does the body produce more energy and stamina when its organs, blood vessels, and central nervous system are all operating at optimum levels.

Breaking Down How Stem Cell Therapy Works As An Anti Aging Treatment

So, what are the exact mechanics that allow anti aging treatment through stem cell therapy to lead to optimal health? As mentioned above, stem cells are the building blocks from which all repair, regeneration, and healing of the body arise. Every cell of the body “stems” from them. Hence, the name “stem cell.”

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